Comparison between herbs used for the treatment of gastroesophageal reflux diseases (GERD)

Background:An abnormality that causes reflux is termed as Gastroesophageal reflux disease (GERD), which is symptomatic by nature and adds to the long-term effects.Objective:The aim of this study is to observe and monitor the effects of a herbal ttratment of GERD with SiniZuojin Decoction (SNZID)and to assess its mediation impacts regarding the use of the medication in patients with Gastrointestinal EBB ailment.Materials and Methods:The cohort research methodology was used inthe study.The research included 2581 individual patients who were older than 18 years of age and were suffering from Gastrointestinal ebbailment. The patients were selected from various government herbal clinics in eastern China, including the states of Anhui, Fujian, Jiangsu, Jiangxi, Shandong, and Zhejiangover, from 2008 to 2018. Results:The study was conducted with a total of 2581 patients. The thorough assessment indicated that Sini Zuojin Decoction (SZD)notwithstanding standard stomach remedies pack was more effective than the traditionalist stomach suppositories bundle (RR=1.34, with CI=95% [1.47, 1.38], and P-value = 0.008); Test packs including SZD was essentially better contrasted with traditional stomach medicines(TSM)gearshifts in developing dyspepsia, substernal chest plague, decreasing regurgitation, and vomiting (P < 0.0002); SNZJD plus traditional stomach medicines(SPTSM)could by and large lessen full-scale sign scores with liberal ampleness (P < 0.00002). The replication degree and antagonistic effects regarding Sacroiliac Joint Dysfunction(SJD)treatment were basic. As confirmed through the TSA regarding thorough assessment, the results were significant, yet repeat security consequences were uncertain. As shown by the computation of the Grading of Recommendations Assessment, Development and Evaluation(GRADE)strategy, the idea regarding verification was minimal. Moreover, Schizoaffective disorder(SZD)may treat Gastrointestinal ebb ailment by presenting the onsetof the infection and controlling factors that may contribute to Gastrointestinal ebb ailments.Conclusion:The research evaluated the efficiency of Sini Zuojin Decoction in treating patients suffering from Gastrointestinal Ebb Ailments. [Ethiop. J. Health Dev.2022: 36(2) (00-00)]Keywords:GERD, Esophagitis, Sini Zuojin Decoction(SZD), Gastrointestinal ebb ailment;

Evaluation of Antiulcer Properties of Ethanolic and hot Aqueous Stem Extracts of Synclisia Scabrida on Experimentally Induced Ulcer Models in Albino Mice

The treatment of peptic ulcer disease poses therapeutic challenges to both patients and physicians alike because of the tendency of ulcers to relapse. Drugs used in the treatment of this disease are either costly or are associated with high incidence of adverse effects. Synclisia scabrida is a plant used in ethnomedicine for the treatment of various forms of stomach disorders and menstrual pains. The medicinal properties of the plants are claimed to reside in the roots; stems; and the leaves. Aim : This study; therefore; is to verify this claim and elucidate the probable mechanism of action by using crude stem extracts of this plant on drug- and stress-induced ulcer models in albino mice. Materials and Methods : Crude ethanol and hot water extracts; EE and HWE respectively; of the stem were prepared. These extracts were fractionated and separated by chromatographic methods and the fractions pooled together as fractions (PF-1; PF-2; PF-3 respectively) based on their chromatographic mobility and color reactions. Phytochemical analysis was done on the extracts. Ulcer models were induced in albino mice by means of indomethacin; histamine; and stress after prior cytoprotection with orally administered crude extracts and control (cimetidine). Results : Phytochemical analysis of the crude extracts and their fractions revealed the presence of cardiac glycosides (+++); tannins (+++); saponins (+); flavonoids (++); carbohydrates (++) and alkaloids (+++). Acute toxicity study on the crude extracts and their fractions revealed relative safety at the dose of 5000 mg/kg. The crude extracts (EE and HWE) and their fractions (PF-1; PF-2; PF-3) significantly (P = 0.001) protected against indomethacin-; histamine- and stress-induced ulcers. The decrease in GIT motility produced by these extracts was comparable to that produced by atropine sulfate. Conclusion : The findings suggest that these extracts of Synclisia scabrida possess antiulcer and antispasmodic properties; which justify the claims for its use in the treatment of various forms of stomach disorders

Contribution a la connaissance des plantes medicinales du Haut Zaire : plantes utilisees dans le traitement des maux d'estomac dans la ville de Kisangani

L'enquete ethnobotanique faite sur les plantes utilisees contre les maux d'estomac a conduit a la recolte de 50 especes vegetales; representees surtout par des phanerophytes; a distribution pantropicale et souvent cultivees. Les medicaments sont generalement prepares a base des feuilles et secondairement a partir des ecorces de tronc; des fruits ou des plantes entieres. Les recettes sont preparees sous forme de decocte et de macere aqueux et prescrites par voie orale dans la plupart des cas. sur les 50 especes vegetales recensees; 19 sont citees dans la litterature pour les memes usages

Compte-rendu fibroscopique de 188 lesions oesogastro-duodenales chez les 5-20 ans a l'Hopital du Point G - Bamako

Ce travail est une etude retrospective effectuee a partir des registres du Service d'Endoscopie digestive de l'Hopital du Point G. Il s'est etendu de janvier 1993 a mars 1995. L'objectif a ete d'evaluer la frequence des affections oeso-gastro-duodenales chez les sujets de 5 a 20 ans. Sur 5633 endoscopies realisees; la pathologie oeso-gastro-duodenale a ete analysee chez les sujets de 20 ans : soit 302 sujets (5;5 pour cent de la pathologie totale). Au total; 188 etaient pathologiques (62;3 pour cent de la population etudiee et 3;3 pour cent de l`ensemble des examens effectues). La tranche d`age de 16 a 20 ans a ete la plus representee; 66;4 pour cent (n = 125) et celle de 5 a 10 ans la moins representee; 2;7 pour cent (n = 5). Les hommes ont constitue 49;5 pour cent (n = 93) et les femmes 50;5 pour cent (n = 95) de la population etudiee. Les sujets de 5 a 15 ans representent 13;2 pour cent (n = 25) et les plus de 15 ans; 86;8 pour cent (n = 163). Il est ressorti de cette etude que les lesions gastriques predominaient

Etude epidemiologique des affections oeso-gastro-duodenales au Mali au moyen de la fibroscopie digestive haute

L'objectif principal a ete d'evaluer au moyen de la fibroscopie digestive haute la frequence des affections oeso-gastro-duodenales au Mali. Sur 2864 examens pratiques; 1963 (68;54 pour cent) ont permis la decouverte de 2386 lesions (associations frequentes de differentes lesions). L'estomac a ete le plus frequemment touche (54;27 pour cent). Les gastrites ont domine la pathologie (46;19 pour cent). L'homme jeune de 21 a 40 ans a ete le plus affecte. Le symptome le plus frequent a ete l'epigastralgie. Il n'a ete constate aucune particularite quant a l'ncidence des anomalies constatees; selon la profession; la residence et l'ethnie